tumeEphethy (not verified) says:

An early, effective treatment of acne was high doses of the fat-soluble vitamin A. At these dose levels (sometimes 500,000 IU per day) effects such as reduced production of sebum and dry hair could be noticedneeded]. However the vitamin also had many other prominent side effects which inhibited its widespread useneeded].
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Decreases in red blood cell parameters, decreases in white blood cell counts (including severe neutropenia and rare reports of agranulocytosis; see PRECAUTIONS: PATIENT INFORMATION), elevated sedimentation rates, elevated platelet counts, thrombocytopenia
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St. John's Wort: Accutane use is associated with depression in some patients (see WARNINGS: Psychiatric Disorders and ADVERSE REACTIONS: Psychiatric).

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