Harlem still has decent apartments for rent at lower than the average price. Also - condos and coops can still be found in Harlem that does make it the most affordable area of Manhattan (other than Washington Heights).

The Bronx does not have as many transportation options though. Harlem up to 145th is served very well with Public Transit including the express stops at 145th and 125th streets (midtown in less than 10 minutes).

Something to think about before abandoning Manhattan altogether!